Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX)

There is a need for interventions to reduce frailty in older people with Alzheimer's dementia (AD). The purpose of this study was investigate the effect home-based multimodal exercise program adults AD (AD-HOMEX) on frailty. A parallel single-blind randomized controlled trial comparing and usual care. Brazil. Forty individuals aged 65 years or mild moderate AD. intervention group (IG) participated 16-week protocol involving three 60-minute sessions per week progressive individualized physical exercises supervised by therapist. participants control (CG) maintained their Frailty assessed using FRAIL questionnaire, Edmonton Frail Scale (EFS) subjective assessment evaluator (SAE) at baseline follow-up. Per-protocol analysis performed. Thirty-five completed (IG = 16; CG 19). improved IG based EFS (P .004) ? .001). An interaction between time .008) significant difference times .047) were found SAE responsiveness domain. improvement classification (EFS FRAIL) .003) groups follow-up .027). .034), worsening .032). Interestingly, more favorable transition pattern both FRAIL. AD-HOMEX seems improve patterns. Our findings provide further theoretical basis designing as routine practice frail